Description_x000D_ Application_x000D_ Verapamil hydrochloride has been used:_x000D_ • to inhibit calcium oscillation in fertilized oocyte_x000D_ • to block calcium channel, thereby blocking the action of IL-1β (interleukin-1β), resulting in membrane depolarization_x000D_ • to investigate the effect of verapamil on cytotoxicity of 1,3-dilinoleoylglycerol (DLG)_x000D_ Packaging_x000D_ 1, 5, 10 g in glass bottle_x000D_ Biochem/physiol Actions_x000D_ α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6._x000D_ Features and Benefits_x000D_ This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC