Description; General description; (−)-Blebbistatin, a myosin II ATPase inhibitor, does not affect other members of myosin superfamily like I, V and X. Blebbistatin is highly light sensitive,[1] and photobleaching can reverse its effect completely.[2] Blebbistatin is a commonly used as excitation-contraction uncoupling agent in cardiovascular physiology.[1][2] Blebbistatin controls the inhibitory effect of thrombin on intercellular Ca2+ wave propagation.[3] Blebbistatin reduces cardiac contractility by stabilizing the OFF state of the thick filament.[4]; Application; (−)-Blebbistatin has been used to investigate the effect on cardiac contractility [4] and effect of thrombin on actomyosin contractility[3]; Packaging; 1, 5 mg in glass bottle; Biochem/physiol Actions; (-)-Blebbistatin is a cell cycle inhibitor; selective inhibitor of non-muscle myosin II.; Features and Benefits; This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.