Description_x000D_ General description_x000D_ Cotinine is an alkaloid extracted from tobacco leaves. It can cross the blood-brain barrier. Cotinine is used to treat Alzheimer′s disease (AD), schizophrenia and post-traumatic stress disorder (PTSD)._x000D_ Application_x000D_ Cotinine has been used:_x000D_ • for oxygen-glucose deprivation (OGD) studies to model ischemic stroke_x000D_ • as a standard to determine serum cotinine measurements using liquid chromatography with tandem mass spectrometry (LC-MS/MS)_x000D_ • to evaluate the adverse developmental potential of cotinine_x000D_ • to assess cognitive behavior in mice_x000D_ Packaging_x000D_ 1 g in glass bottle_x000D_ 250 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Major metabolite of nicotine in humans._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC