Description General description Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease. Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease. Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target γ-secretase Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Sequence Z-Leu-Leu-Nle-CHO (Nle = Norleucine) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Skovronsky, D.M., et al. 2000. Biochemistry 39, 810. Hartmann, T., et al. 1997. Nat. Med. 3, 1016.