Description General description 1,4-Dithiane-2,5-diol undergoes bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction with chalcones to afford trisubstituted tetrahydrothiophenes. It participates in diastereoselective [3+3] cycloaddition with azomethine imines catalyzed by 1,4-diazabicyclo[2.2.2]octane. It is a mercaptoacetaldehyde dimer and an efficient synthon for incorporating a thiol group to in situ generated nitroalkenes. Application 1,4-Dithiane-2,5-diol was used in the synthesis of: • substituted tetrahydrothiophene derivatives • 2-amino-3-(arylsulfonyl)thiophenes, potential antiviral and antitumor agents Packaging 50, 250 g in glass bottle