Description General description A 452-amino acid glycoprotein present in plasma at about 70 µg/ml. Efficiently inhibits the plasminogen activator-induced lysis of fibrin clots. Forms a covalent complex with plasmin and inactivates it. A 452-amino acid glycoprotein present in plasma at about 70 µg/ml. Efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots. Forms a covalent complex with plasmin and inactivates it. Packaging 100 μg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target Plasminogen activator-induced lysis of fibrin clots Product does not compete with ATP. Reversible: no Warning Toxicity: Standard Handling (A) Unit Definition One Inhibitory Unit (I.U.) is defined as the amount of enzyme that will inhibit 1 unit plasmin activity using tosyl-Gly-Pro-Lys-pNA as substrate at 25°C, pH 7.8 Physical form Lyophilized from 200 mM NaCl, 20 mM Bis-Tris, pH 6.4. Preparation Note Please refer to the vial label for the lot-specific reconstitution volume. Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Schaefer, B.M., et al. 1996. Arch. Dermatol. Res. 288, 122. Aoki, N., et al. 1980. Blood 55, 483. Saito, H., et al. 1974. Circ. Res.34, 641.