Description General description A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum. Packaging 50 mg in Glass bottle Packaged under inert gas Warning Toxicity: Toxic (F) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Beal, M., et al. 1993, J. Neurosci.13, 4181. Pang, Z., et al. 1997, J. Neuroscience17, 3064. Huang, L., et al. 2006, J. Bio. Chem. 281, 5965. Garcia, M., et al. 2002, J. Neurosci. 22, 2174. Kim, G. W., et al. 2003, J. Neurosci.23, 8733. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.