Description General description Potent and specific inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50 = 230 nM). Elevates the intracellular cGMP level without causing a change in the cAMP level in isolated porcine coronary arteries. Has no effect on other PDE isoenzymes. Potent and specific inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 230 nM). Elevates the intracellular cGMP level without causing any change in the cAMP level in isolated porcine coronary arteries. Has no effect on other PDE isozymes. Packaging 5 mg in Glass bottle Biochem/physiol Actions Primary Target CGMP-PDEV Warning Toxicity: Standard Handling (A) Other Notes Takase, Y., et al. 1994. J. Med. Chem.37, 2106.