Description_x000D_ Amino Acid Sequence_x000D_ Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro_x000D_ General description_x000D_ Adrenocorticotropic hormone (ACTH), also called proopiomelanocortin (POMC), is a 303-amino acid hormone protein. Proteolysis of ACTH results in active peptides. ACTH is mapped to human chromosome 2p23.3._x000D_ The portion of the ACTH sequence that is conserved across species; has ~75% of the potency of ACTH on a molar basis._x000D_ Application_x000D_ Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay and to induce color change in frogs._x000D_ Biochem/physiol Actions_x000D_ Adrenocorticotropic hormone (ACTH) activates melanocortin receptor (MC1R to MC5R) and plays a key role in generation of α-melanocyte-stimulating hormone (α-MSH). The loss of function mutations in ACTH gene is implicated in obesity and red hair. Hypomethylation of POMC promoter region in thymic carcinoids is associated with ectopic adrenocorticotropic hormone syndrome. POMC mutation results in generation of abnormal fusion protein, impairing melanocortin signalling in hypoadrenalism. Dysregulation of ACTH gene transcription impacts metabolic pathways leading to Cushing disease._x000D_ Other Notes_x000D_ Lyophilized from 0.1% TFA in H2O