Description General description AEBSF, CAS 30827-99-7, is a specific irreversible inhibitor of chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. A nontoxic alternative to PMSF and DFP. Specific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K. Specific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPUα) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications. Also available as a 50 mM solution in H2O (Cat. No. 508436). Packaging 1 g in Glass bottle 500 mg in Plastic ampoule 50, 100 mg in Glass bottle Packaged under inert gas Biochem/physiol Actions Primary Target chymotrypsin Product does not compete with ATP. Warning Toxicity: Standard Handling (A) Reconstitution Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 2 months at 4°C. Slight hydrolysis occurs at alkaline pH (8-9). Other Notes Citron, M., et al. 1996. Neuron 17, 171. Ohkubo, I., et al. 1994. J. Biochem. 116, 1182. Mintz, G.R. 1993. BioPharm. 6, 34. Lawson, W.B., et al. 1982. Folia Haematol.109, 52. Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247. Markwardt, F., et al. 1973. Thromb. Res.2, 343. Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.