Description General description A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation. Packaging 10 mg in Glass bottle Packaged under inert gas Warning Toxicity: Standard Handling (A) Other Notes Platzer, B., et al. 2009. J. Immunol.183, 66. Hauben, E., et al. 2008. Blood118, 1214. Lawrence, B.P., et al. 2008. Blood112, 1158. Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med.173, 599.