Description_x000D_ General description_x000D_ ABCB5 (ATP binding cassette subfamily B member 5) gene is located in human chromosome 7p21.1. The encoded protein belongs to the subfamily B multidrug resistance and ATP-binding cassette superfamily of active transporters. The encoded protein have two identical halves, each contains a hydrophobic region with six transmembrane segments and a nucleotide-binding region. Expression of this gene is observed in prostate and testis and in human melanoma tumor-initiating cells._x000D_ ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules._x000D_ Immunogen_x000D_ ABCB5 (NP_848654, 3-35)_x000D_ This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ABCB5._x000D_ Application_x000D_ Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below._x000D_ Flow cytometry/Cell sorting (1 paper)_x000D_ Physical form_x000D_ Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ ABCB5 (ATP binding cassette subfamily B member 5) is a cell surface marker for melanoma-initiating cells, on cellular metabolism. ABCB5 significantly regulates glycolysis, glutaminolysis and phospholipid metabolism. It induces stem cell differentiation, stem cell immortality and anti-apoptotic activity. The gene is upregulated in many cancer subtypes, including breast cancer. Recent studies reveal that ABCB5 is a novel marker for limbal stem cell and is needed for corneal development and repair. ABCB5 shows resistance against taxanes and anthracyclines, the anti-cancer drugs.