Description_x000D_ General description_x000D_ Anti-ADAMTS1, a mouse polyclonal antibody, recognizes human ADAMTS1 protein. It is validated for ELISA, and Western blotting._x000D_ Purified mouse monoclonal antibody. Recognizes the ADAMTS1 protein._x000D_ Recognizes the ADAMTS1 protein._x000D_ This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function._x000D_ Immunogen_x000D_ A recombinant polypeptide corresponding to amino acids 858-968 of human ADAMTS1, expressed as a GST fusion protein_x000D_ Application_x000D_ _x000D_ ELISA (see comments)_x000D_ Immunoblotting (1-5 µg/ml)_x000D_ Physical form_x000D_ In PBS, pH 7.27._x000D_ Reconstitution_x000D_ Following initial thaw, aliquot and freeze (-20°C)._x000D_ Warning_x000D_ Toxicity: Regulatory Review (Z)_x000D_ Other Notes_x000D_ For ELISA, this antibody can be used as the capture antibody; recommended concentration is 10 ng/ml, 1 µg/well, 100 µl total volume. Variables associated with assay conditions will dictate the proper working dilution.