Description_x000D_ General description_x000D_ Adiponectin is secreted from adipose tissue for the regulation of glucose and fatty acid break down._x000D_ Anti-Adiponectin is produced in rabbit using a synthetic peptide corresponding to amino acid residues of human adiponectin. Adiponectin, also designated as adipocyte complement-related protein of 30 kDa (Acrp30), AdipoQ, apM1, Gelatin-binding protein 28 kDa (GBP28) is an adipocyte-specific protein that circulates in the blood stream, where it accounts for approximately 0.01% of all plasma proteins. Adiponectin belongs to the complement factor C1q family that belongs to the soluble defense collagen superfamily. Adiponectin (ADIPOQ) protein has a carboxyl-terminal globular domain and an amino-terminal collagen domain._x000D_ Specificity_x000D_ Rabbit Anti-Adiponectin antibody recognizes human and mouse adiponectin._x000D_ Immunogen_x000D_ synthetic peptide corresponding to amino acid residues 225-244 of human adiponectin with N-terminal added cysteine, conjugated to KLH._x000D_ Application_x000D_ Anti-Adiponectin antibody produced in rabbit has been used in western blotting and immunohistochemistry._x000D_ Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below._x000D_ Western Blotting (1 paper)_x000D_ Rabbit Anti-Adiponectin antibody has been used for immunohistochemical and western blot applications._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Adipose tissue has important roles in energy storage, glucose homeostasis and fat metabolism.(10) Increased adiponectin levels are associated with type I diabetes mellitus, anorexia nervosa, weight reduction, and chronic renal failure. Adiponectin (ADIPOQ) affects lipid catabolism by increasing fatty acid oxidation in muscle, modulates glucose uptake, alters liver gluconeogenesis and enhances insulin-sensitivity in both muscle and liver. ADIPOQ has anti-atherosclerotic and anti-inflammatory properties. ADIPOQ has a role in physiological processes such as energy homeostasis and obesity. Low levels of adiponectin are also linked with hypertension and dyslipidemia. Mutation in the gene encoding it is linked with risk for endometrial cancer.