Description_x000D_ General description_x000D_ β-site amyloid precursor protein- cleaving enzyme 2 (BACE2) is a glycoprotein which is part of the transmembrane aspartic protease family. The gene encoding this protein is localized on human chromosome 21q22.3._x000D_ Immunogen_x000D_ a synthetic peptide corresponding to amino acids 44-59 of human BACE2._x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 0.02% sodium azide_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ β-site amyloid precursor protein- cleaving enzyme 2 (BACE2) has a role in the non-amyloidogenic processing of amyloid precursor protein. It also possesses an amyloid β-degrading protease activity. Cells of individuals with Down’s syndrome show an enhanced expression of BACE1 mRNA and the protein._x000D_ Linkage_x000D_ The action of this antibody can be blocked using blocking peptide SBP2247.