Description_x000D_ Immunogen_x000D_ Immunogen Sequence: GI # 6552299, sequence 1395-1454_x000D_ Recombinant breast cancer 1, early onset isoform 1_x000D_ Application_x000D_ Anti-BRCA1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200._x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 0.02% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ BRCA1 is a human tumor suppressor gene. Its main function is to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest and transcriptional regulation. BRCA1 is associated with breast and ovarian tumor suppression. Mutations in BRCA1 is involved in the pathogenesis of breast and ovarian cancer. BRCA1 promoter methylation is associated with better response to platinum-taxane-based therapy in epithelial ovarian cancer (EOC). BRCA1 mutation may drive the formation of tumors in estrogen-regulated tissues.