Description_x000D_ General description_x000D_ The gene CACNB4 (Calcium channel voltage-dependent subunit beta 4) is mapped to human chromosome 2q22-23. It is present at the membrane as well as the nucleus._x000D_ Specificity_x000D_ Specifically recognizes a splice variant of β4 (55 kDa)._x000D_ Immunogen_x000D_ synthetic peptide derived from the rat β4 calcium channel subunit conjugated to KLH._x000D_ Application_x000D_ Anti-Calcium Channel (β-4 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10μg/mL using brain tissue lysate._x000D_ The antibody has been used for:_x000D_ • western blotting of proteins extracted from different brain regions of the mouse_x000D_ • western blotting of proteins isolated from primary culture of mouse cerebral cortical neurons_x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 0.08% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ The CACNB4 (Calcium channel voltage-dependent subunit β 4) is an intracellular regulatory subunit of voltage-activated calcium channels that has significant impact on membrane expression and electrophysical characteristics of the channel. Calcium channel β subunits regulate voltage-dependent calcium currents through direct interaction with α1 subunits. Mutations in CACNB4 are associated with idiopathic generalized epilepsy and episodic ataxia. CACNB4 interacts with heterochromatin protein 1γ (HP1γ). The interaction attenuates the gene silencing activity by HP1.