Description_x000D_ General description_x000D_ Calcium channel, voltage-dependent, T type, α 1G subunit is a protein encoded by CACNA1G gene in humans. It belongs to a family of voltage-gated calcium channels and serves as the key transducer of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events._x000D_ Immunogen_x000D_ peptide corresponding to amino acid residues 1-22 of rat CaV3.1. This epitope is highly homologous in human (20/22 residues identical)._x000D_ Application_x000D_ Anti-Calcium Channel CaV3.1 (α1G) antibody produced in rabbit is suitable for western blotting at a dilution of 1:200 using rat brain membranes._x000D_ Physical form_x000D_ Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ CACNA1G (T-type channels) are involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance and rebound burst firing. It exhibits a significant window current that helps for Fe2+ pathway entry into cells with relevant concentrations of extracellular Fe2+. The window current also creates a pathway for Cd2+ entry into cells during Cd2+ exposure. CACNA1G were found to be associated with Autism Spectrum Disorder.