Description_x000D_ General description_x000D_ Anti-CCR7 antibody detects endogenous level of total CCR7(CD197) protein. CCR7 (C-C motif chemokine receptor 7) is localized to T cells, natural killer and dendritic cells. The CCR7 gene is mapped to human chromosome 17q21.2._x000D_ Immunogen_x000D_ Peptide sequence around aa. 29-33 (T-D-D-Y-I), according to the protein NP_001829.1_x000D_ Target description_x000D_ Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions._x000D_ Physical form_x000D_ Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ CCR7 (C-C motif chemokine receptor 7) regulates lymphocyte cell trafficking and lymph node distribution. CCR7’s interaction with CCL21 promotes metastasis of cancer via lymph node. CCR7 is known to be associated with breast cancer, melanoma, colorectal cancer, non-small cell lung cancer, and chronic lymphocytic leukemia._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.