Description_x000D_ General description_x000D_ Monoclonal Anti- CD3ζ chain (mouse IgG1 isotype) is derived from the hybridoma TCR-48 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of mouse CD3ζ chain conjugated to KLH. CD3ζ is a 16-kDa transmembrane protein, which consists of a short extracellular domain and a long intracellular domain including immunoreceptor tyrosine-based activation motif (ITAM). It is a subunit of T cell receptor chains (TCR), which is expressed by T cells and natural killer (NK) cells._x000D_ Application_x000D_ Monoclonal Anti-CD3ζ chain antibody produced in mouse has been used in immunoblotting and immunoprecipitation._x000D_ Physical form_x000D_ Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ CD3ζ is required for T cell receptor chains (TCR) complex assembly and expression. It is involved in immunity, neuronal development and synaptic plasticity. Downregulation of TCR ζ-chain expression and impairment of T-cell function is associated with systemic lupus erythematosus (SLE), rheumatoid arthritis, cancer and infectious diseases. Altered expression and function of CD3ζ in T cells is linked to hematological diseases.