Description_x000D_ General description_x000D_ CHAF1B (Chromatin assembly factor 1, subunit B) is a large subunit (60kDa) of Chromatin assembly factor 1 (CAF-1) located on chromosome 21q22.2. It is predominantly expressed in nucleus._x000D_ Immunogen_x000D_ Synthetic peptide directed towards the C terminal region of human CHAF1B_x000D_ Application_x000D_ Anti-CHAF1B antibody produced in rabbit is suitable for immunohistochemistry and western blot applications._x000D_ Physical form_x000D_ Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ CHAF1B (Chromatin assembly factor 1, subunit B) is involved in the S-phase-specific organization of nucleosome of DNA strand during DNA replication and repair. It mediates the first step of nucleosome assembly by arranging newly synthesized histones H3 and H4 to replicating DNA. It has been reported in a study that silenced gene expression of CHAF1B is associated with cell death and loss of chromatin assembly during DNA synthesis. CHAF1B also has been suggested as a prognostic marker in renal, endometrial and cervical carcinomas._x000D_ Sequence_x000D_ Synthetic peptide located within the following region: PPSSVPTSVISTPSTEEIQSETPGDAQGSPPELKRPRLDENKGGTESLDP