Description_x000D_ General description_x000D_ Claudin-5 is a member of claudin family. It is also known as CLDN5, beclin 1, TMVCF and CPETRL1 and is highly expressed in endothelial cells (ECs), including the blood-brain barrier._x000D_ Immunogen_x000D_ synthetic peptide corresponding to an internal sequence of human claudin-5, conjugated to KLH. The corresponding sequence is highly conserved (single amino acid substitution) in mouse and rat claudin-5._x000D_ Application_x000D_ Anti-Claudin-5 antibody produced in rabbit may be used in several immunochemical techniques including immunoblotting (~23 kDa) and immunohistochemistry._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Claudin-5 gene is a downstream target of ETS-related gene (ERG), a transcription factor that regulates endothelial cell-restricted genes and is markedly repressed in response to inflammatory stimuli. Knockout of claudin-5 in mice is lethal, resulting in disruption of in the blood-brain barrier. Claudin-5 has been shown to be overexpressed in various tumors including lung adenocarcinomas but undetectable in squamous cells cell carcinomas.