Description_x000D_ General description_x000D_ CX3CR1 (chemokine (C-X3-C motif) receptor 1) is a surface receptor for chemoattractant cytokines. It is expressed by circulating monocytes, tissue macrophages and dendritic cells, T cells and natural killer (NK) cells. It acts as a receptor for CX3CL1 chemokine. In brain, it is expressed only in microglial cells._x000D_ Immunogen_x000D_ Immunogen Sequence: GI # 4503171, sequence 1-21_x000D_ Recombinant chemokine (C-X3-C motif) receptor 1_x000D_ Application_x000D_ Anti-CX3CR1 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200._x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 0.02% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ CX3C chemokine receptor 1 (CX3CR1) plays an important role in modulating inflammatory responses that includes monocyte homeostasis and macrophage phenotype and function. CX3CR1 is associated with angiogenic macrophage survival in the tumor microenvironment contributing to tumor metastasis. It is implicated as a candidate gene for age-related macular degeneration (AMD). CX3CR1 polymorphisms may influence the incidence and the outcome of acute myocardial infarction.