Description_x000D_ General description_x000D_ Dcp1 colocalizes with Dcp2 in distinct cytoplasmic foci along with other proteins involved in the 5’ to 3’ mRNA decay. These foci are termed PB (processing bodies) or DCP-bodies. DCP1A and DCP1B are the two distinct genes of human DCP1. They share ~70% homology in their N-termini and ~30% homology in their full length._x000D_ Human cells consists of two decapping protein 1a (DCP1a) homologues, hDcp1a and hDcp1b, that are coded by two distinct genes._x000D_ Application_x000D_ Anti-DCP1A (N-terminal) antibody produced in rabbit has been used in:_x000D_ • immunoblotting_x000D_ • immunofluorescence_x000D_ • immunoprecipitation_x000D_ Physical form_x000D_ Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Dcp1 cleaves the m7G mRNA cap in the 5’ to 3’ mRNA decay pathway. Decapping is a critical and highly regulated step in the turnover of mRNA which involves decapping enzymes that hydrolyze the cap structure at the 5’ mRNA._x000D_ Human decapping protein 1a (hDCP1a) acts as a processing body (PB) marker.