Description_x000D_ Immunogen_x000D_ synthetic peptide from the extracellular loop 2 region of human dopamine transporter._x000D_ Application_x000D_ Anti-Dopamine Transporter, Extracellular Loop 2 antibody produced in rabbit is suitable at a working dilution of 1:1000 for western blotting using SDS-solubilized human striatal samples and for immunohistochemistry using formaldehyde-fixed human and monkey brain sections._x000D_ Target description_x000D_ The dopamine transporter (DAT1) acts to take released dopamine back up into presynaptic terminals and has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse._x000D_ Physical form_x000D_ Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ The dopamine transporter (DAT1) acts to take released dopamine back up into presynaptic terminals and has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse. DAT1 gene is a primary target gene for ADHD (Attention deficit hyperactivity disorder). DAT polymorphism along with maternal prenatal smoking is associated with childhood hyperactivity-impulsivity and inattentiveness.