Description_x000D_ Immunogen_x000D_ synthetic peptide corresponding to amino acids 328-344 of human EDG-2/LPA1._x000D_ Application_x000D_ Anti-LPA1, C-Terminal antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat brain microsomal fraction._x000D_ Physical form_x000D_ Solution in 0.2 mM sterile-filtered Ca2+- and Mg2+- free Dulbecco′s PBS, containing 0.05% sodium azide_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Lysophosphatidic acid receptor 1 (LPA1) is a protein encoded by the LPAR1 gene in humans. It is constitutively localized in the nucleus of mammalian cells and may be involved in regulating intranuclear protein phosphorylation and signalling. LPA1 is differentially expressed in androgen-insensitive and LPA-responsive cells. It is not expressed in androgen-dependent and LPA-resistant cells.Its expression is significantly higher in the cancer compared with the benign tissues and may possibly act as a drug target to interfere with progression of prostate cancer. LPA1 helps in promoting cell proliferation, survival and migration by acting on cognate G protein-coupled receptors.