Description_x000D_ General description_x000D_ The gene ELP3 (elongator complex protein 3) is mapped to human chromosome 8p21.1. The encoded protein has a HAT (histone acetyltransferase) domain._x000D_ Immunogen_x000D_ ELP3 (NP_060561, 14-54)_x000D_ This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ELP3._x000D_ Physical form_x000D_ Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ ELP3 (elongator complex protein 3) is a catalytic subunit of the histone acetyltransferase elongator complex. It enhances histone H3 acetylation, thereby regulating gene regulation in neurons. Dysregulation of ELP3 activity causes neuronal disorders, such as familial dysautonomia and amyotrophic lateral sclerosis. It might be a potential acetyltransferase for glucose-6-phosphate dehydrogenase. The ELP3 gene promoter is hypermethylated in invasive ductal breast carcinoma, causing transcriptional inactivation of the gene.