Description_x000D_ General description_x000D_ The estrogen receptor 1 (ESR1) gene is mapped to human chromosome 6q25.1-q25.2. The encoded protein belongs to the nuclear hormone receptor family. ESR1 is characterized with a transcription activation function-1 domain (AF-1), a DNA-binding domain (DBD), a hinge domain and a ligand-binding domain (LBD/AF-2)._x000D_ Immunogen_x000D_ Peptide sequence around aa. 165-169 (L-A-S-T-N), according to the protein ESR1._x000D_ Target description_x000D_ Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues._x000D_ Physical form_x000D_ Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Estrogen receptor 1 (ESR1) is involved in immune and inflammatory response. Aberrations in ESR1 results in Mayer-Rokitansky-Küster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina. Polymorphism in the gene increases the risk of susceptibility to fractures. Elevated expression of the gene has been observed in breast cancer patients._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.