Description_x000D_ General description_x000D_ Fructose-1,6-bisphosphatase 1 (FBP1) gene is located on human chromosome 9q22.32. FBP1 is an allosteric enzyme, which is regulated by different enzymes. It has two isozymes, expressed in liver and muscle._x000D_ Immunogen_x000D_ FBP1 (NP_000498.2, 1 a.a. ~ 338 a.a) full-length human protein._x000D_ Sequence_x000D_ MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ_x000D_ Physical form_x000D_ Solution in phosphate buffered saline, pH 7.4_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Fructose-1,6-bisphosphatase 1 (FBP1) deficiency is an inherited autosomal recessive disease. FBP1 is important in the carcinogenesis of different cancers. It promotes chemoresistance in cervical cancer. FBP1 is a tumor suppressor, which is downregulated in cancers. It regulates the Wnt/β-Catenin pathway in breast cancer.