Description_x000D_ General description_x000D_ Glucose/regulated protein 78 (GRP78) is a stress-associated protein. It is mapped to human chromosome 9q33.3. It is also known as HSPA5 (heat shock 70kDa protein 5) and immunoglobulin heavy chain binding protein (BiP). It is present in nucleated cells like thyroid, lung, smooth muscle, liver and several cells of the immune system._x000D_ The molecular weight of GRP78 is 78kDa._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human GRP78._x000D_ Immunogen Range: 605-654_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ GRP78 levels are elevated during various human cancers and tumors._x000D_ Glucose/regulated protein 78 (GRP78) participates in stress-associated diseases. It also participates in protein biogenesis (protein transport into the endoplasmic reticulum (ER), protein folding and assembly and ER associated protein degradation), signal transduction and calcium homeostasis._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.