Description_x000D_ General description_x000D_ Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of an alpha and a beta subunit. The enzyme converts GTP into the second messenger cGMP and plays a major role in the cardiovascular system as a receptor for nitric oxide. Unlike other guanylyl cyclases, GUCY1B2 contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation._x000D_ Immunogen_x000D_ GUCY1B2 (NP_004120, )_x000D_ This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GUCY1B2._x000D_ Physical form_x000D_ Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.