Description_x000D_ General description_x000D_ Immunoglobulin G (IgG) is part of the immunoglobulin family. It is a widely expressed serum antibody, consisting of a γ heavy chain in the constant (C) region. It has a monomeric 150kDa structure, with two identical heavy chains and two identical light chains. They have a molecular weight of 50kDa and 25kDa, respectively. The primary structure of the antibody also contains disulfide bonds involved in linking the two heavy chains, linking the heavy and light chains and resides inside the chains. IgG is further subdivided into four classes namely, IgG1, IgG2, IgG3, and IgG4 with different heavy chains, named γ1, γ2, γ3, and γ4, respectively. Limited digestion with papain cleaves the antibody into three fragments, two of which are identical and contain the antigen-binding activity. They are known as fragment antigen binding (Fab) fragments. These fragments contain the light chains paired with the VH and CH1 domains of the heavy chains._x000D_ Specificity_x000D_ This product was prepared from monospecific antiserum by immunoaffinity chromatography using Guinea Pig IgG coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against Anti-Goat Serum, Guinea Pig IgG, Guinea Pig IgG F(ab’)2 and Guinea Pig Serum. No reaction was observed against Guinea Pig IgG F(c)._x000D_ Immunogen_x000D_ Guinea Pig IgG F(ab′)2 fragment_x000D_ Physical form_x000D_ Supplied in 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Physical properties_x000D_ Antibody format: IgG