Description_x000D_ General description_x000D_ Homeobox B4 (HOXB4) gene is mapped to human chromosome 17q21._x000D_ Application_x000D_ Anti-HOXB4 antibody produced in rabbit has been used in immunoblotting and immunofluorescence._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Hox genes helsp to modulate important development pathways that are involved in morphogenesis of the embryo. It also helps in the formation of the body plan during embryonic development. These gene are known to play important roles in normal development, altered homeobox gene function or expression. It is also implicated in the development of cancers, such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin and brain. Homeobox B4 (HOXB4) helps to control the balance between hematopoietic stem cell renewal and differentiation. Suppression of HOXB4 may reverse multidrug resistance (MDR) of K562/ADM cells.