Description_x000D_ General description_x000D_ IgGs are the most common Immunoglobulins isotype in blood, lymph fluid, cerebrospinal fluid, and peritoneal fluid and a key players in the humoral immune response. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4), they consist of a variable Fab fragment (which includes the antibody recognition site), and a conserved Fc fragment. The IgG subclasses differ in their physical and chemical properties, their distribution pattern is found to be age-dependent and every subclass has a specific biological function. IgG deficiencies are often associated with various diseases._x000D_ The Fc fragment has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. A certain population of lymphocytes also possess an "Fc receptor". These functions indicate the importance of immunoreagents specific for the Fc fragment of Human IgG._x000D_ Monoclonal Anti-Human IgG (Fc specific) is specific for the Fc fragment of Human IgG and is observed with all human IgG subclasses but not with the Fab fragment of human IgG, purified light chains, human IgA or human IgM._x000D_ Immunogen_x000D_ Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads._x000D_ Application_x000D_ The antibody is recommended to use in various immunological techniques, including ELISA._x000D_ Physical form_x000D_ Supplied as a lyophilized powder_x000D_ Other Notes_x000D_ This product is for R&D use only, not for drug, household, or other uses.