Description_x000D_ General description_x000D_ Human IgGs consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5 and 4% of the total IgG, respectively. Each subclass has different biological and physiochemical properties. The IgG subclass may be preferentially produced in response to different antigens and pathological conditions. For instance, anti-polysaccharide responses are mainly of the IgG2 subclass while protein antigens give rise to IgG1 and IgG3 antibodies. Human IgG1 is the predominant subclass of in vivo and in vitro produced anti-tetanus toxoid antibodies. IgG1 and IgG3 are the only subclasses capable of adherence to mononuclear phagocytes and are recognized readily by the Fc receptors on various reticulo-endothelial cells while IgG2 and IgG4 are far less efficient._x000D_ The amount of the different IgG subclasses present in the bloodstream varies with age. For example, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels raise more slowly, reaching adult levels at about 10 years of age. Serum IgG subclass deficiencies have been recorded for different patient groups. For example, a disproportionate elevation of IgG1 has been found in the cerebral spinal fluid of patients with multiple sclerosis.Examination of the distribution pattern of IgG subclasses in different types of diseases may provide insight into the immunological processes involved and may assist in the diagnosis of various disorders._x000D_ Monoclonal Anti-Human IgG1 (Fc specific) specifically recognizes Fc region of Human IgG1. The antibody shows no cross-reactivity with human IgG2, IgG3 and IgG4. This clone has been established as a useful human IgG1 specificity standard by the WHO/IUIS._x000D_ Immunogen_x000D_ Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads_x000D_ Application_x000D_ The antibody is recommended to use in various immunological techniques, including ELISA._x000D_ Physical form_x000D_ Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Other Notes_x000D_ This product is for R&D use only, not for drug, household, or other uses.