Description_x000D_ Immunogen_x000D_ Immunogen Sequence: GI # 46575632, sequence 33-111_x000D_ Recombinant interleukin 21_x000D_ Application_x000D_ Anti-Interleukin-21 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200._x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 0.02% sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Interleukin-21 (IL-21) is a protein encoded by the IL21 gene in humans. It is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells. Cytokines are crutial for the regulation of haematopoiesis and immune responses. It can influence lymphocyte development. IL21 has an important role in the proliferation and maturation of natural killer (NK) cell populations from bone marrow. The gene may play a role in the development of Systemic lupus erythematosus (SLE). IL-21 is essential for B cell activation, expansion and PC differentiation induced by direct interaction of B cells with activated T cells. Polymorphisms of this gene is associated with several cancers.