Description_x000D_ General description_x000D_ Mitotic arrest deficient 2 (MAD2) can exist in different folded states and is one of the components of the spindle checkpoint._x000D_ Immunogen_x000D_ recombinant human Mad2 protein._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Mitotic arrest deficient 2 (MAD2) plays a very important role in maintaining the number of chromosomes at the time of cell division. It checks the loss or gain of chromosomes. It delays the separation of premature sister-chromatids by acting on different proteins.It is overexpressed in many types of cancers.