Description_x000D_ Immunogen_x000D_ Immunogen Sequence: GI # 5579478, sequence 1-28_x000D_ Recombinant mitogen-activated protein kinase kinase 1_x000D_ Application_x000D_ Anti-MAP2K1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200._x000D_ Physical form_x000D_ Solution in phosphate buffered saline containing 0.02% sodium azide._x000D_ Biochem/physiol Actions_x000D_ Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme encoded by the MAP2K1 gene in humans and its signaling is one of the most important mechanisms for the cytoplasmic transduction of extracellular signals. MAP2K1 is mapped between chromosomes 15q22.1 and q22.33. It is induced with G2 phase MAPK pathway activation. MAP2K1 is associated with extracellular signal regulated kinases pathway and is involved in regulation of multiple cellular processes that include the cell cycle. Its inhibitors can partially modulate the expression of interferon-stimulated genes.