Description_x000D_ General description_x000D_ Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on human chromosome 11._x000D_ Specificity_x000D_ The antibody recognizes only the latent form of MMP-12 and not the active forms. May be used to distinguish the zymogen and the activated enzyme._x000D_ Immunogen_x000D_ synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-12 (macrophage elastase)._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Matrix metalloproteinase-12 (MMP-12) is involved in breaking down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.