Description_x000D_ General description_x000D_ Matrix metalloproteinase-26 (MMP-26) is also known as endometase and matrilysin-2. It is expressed in normal tissues and also in human carcinoma cells. MMP-26 possesses a propeptide domain, a signal peptide and a catalytic domain but does not have the hemopexin-like domain which is common to other members of its family. The MMP-26 gene is localized to human chromosome 11p15.3._x000D_ Specificity_x000D_ By immunoblotting against the reduced protein, the antibody identifies bands at 30 kDa and 18 kDa (zymogen and active MMP-26, respectively)._x000D_ Immunogen_x000D_ synthetic peptide corresponding to the hinge region of human matrix metalloproteinase-26._x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide._x000D_ Biochem/physiol Actions_x000D_ Matrix metalloproteinase-26 (MMP-26) degrades fibronectin, type IV collagen and activated pro-metalloproteinase-9. MMP-26 also aids in development of tumors.