Description_x000D_ General description_x000D_ Methyltransferase like 3 (METTL3 or M6A) codes for a 70 kDa subunit of MT-A. This protein forms a heterodimeric complex with METTL14 and modulates the methylation of the mammalian nuclear RNA, N6-adenosine._x000D_ Rabbit Anti-METTL3 antibody recognizes bovine, human, mouse, rat, zebrafish, and canine METTL3._x000D_ Immunogen_x000D_ Synthetic peptide directed towards the middle region of human METTL3_x000D_ Application_x000D_ Rabbit Anti-METTL3 antibody is suitable for western blot applications at a concentration of 5 μg/ml._x000D_ Physical form_x000D_ Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine._x000D_ Sequence_x000D_ Synthetic peptide located within the following region: AKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTA