Description_x000D_ General description_x000D_ Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are two major classes of heat stable MAPs; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c)._x000D_ Specificity_x000D_ Reacts with the two major classes of heat stable MAPs (MAP2 and τ). Does not react with MAP1 or tubulin._x000D_ Immunogen_x000D_ heat stable MAPs prepared from bovine brain._x000D_ Application_x000D_ Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit has been used in:_x000D_ • immunofluorescent labelling_x000D_ • immunohistochemistry_x000D_ • immunoprecipitation_x000D_ • immunofluorescence staining_x000D_ • western blotting_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology. Microtubules function as structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton.