Description_x000D_ General description_x000D_ MKS1 (Meckel syndrome, type 1) is novel evolutionarily conserved cytosolic protein localized in basal bodies. Its expression has been found in the brain, liver, kidney and the cartilage tissue of the developing upper limbs. It consists of a B9 domaiIt is mapped on chromosome 17q22._x000D_ Immunogen_x000D_ Recombinant fragment corresponding to a region within amino acids 135 and 357 of MKS1 according to AAH10061_x000D_ Application_x000D_ Anti-MKS1 antibody produced in rabbit is suitable for immunohistochemistry and western blot applictaions._x000D_ Physical form_x000D_ 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative._x000D_ Biochem/physiol Actions_x000D_ MKS1 (Meckel syndrome, type 1) plays a vital role in the primary ciliary movement by functioning as a major component of the “B9” or “Tectonic” complex located at the ciliary transition region. Mutations in the MKS1 gene causes an autosomal recessive disorder, Meckel-Gruber syndrome (MKS), characterized with defects in central nervous system, cystic kidney dysplasia, hepatobiliary ductal plate malformation, and postaxial polydactyly._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.