Description_x000D_ General description_x000D_ MutS Homolog 6 (MSH6) is localized on human chromosome 2p16.3. MSH6 is a 160 kDa protein with nuclear localization sequence and a N-terminal disordered domain. It is a human homolog of E. coli MutS._x000D_ Immunogen_x000D_ synthetic peptide corresponding to amino acids 1311-1327 of human MSH6, conjugated to KLH via an N-terminal added cysteine residue. The immunizing peptide differs from the rat and mouse sequences in one amino acid._x000D_ Application_x000D_ Anti-MSH6 (C-terminal) antibody produced in rabbit has been used in:_x000D_ • immunoblotting_x000D_ • immunoprecipitation_x000D_ • immunofluorescence_x000D_ Physical form_x000D_ Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ MSH6 (also known as GTBP) was isolated from HeLa cells by virtue of its ability to restore mismatch repair to nuclear extracts of MSH2-deficient colorectal tumor cell lines. MutS Homolog 6 (MSH6) is part ofDNA repair pathways and play a key role onmutator S protein (hMutSα) shuttling. MSH6 has ATPase activity that is critical in mismatch repair. Germline mutations in MSH6 is associated with hereditary nonpolyposis colon cancer and in endometrial carcinoma.