Description; General description; NFIL3 (E4BP4) is a basic-leucine zipper transcription factor that has been implicated in cell death, surivival, anti-inflammatory responses and circadian oscillations. Studies have reported that NFIL3/E4BP4 is essential for the growth of NK cells and the survival of pro-B-lymphocytes. Rabbit Anti-NFIL3 antibody recognizes chicken, bovine, canine, human, mouse, rat, and zebrafish NFIL3; Immunogen; Synthetic peptide directed towards the middle region of human NFIL3; Application; Rabbit Anti-NFIL3 antibody can be used for western blot (1μg/ml) applications.; Physical form; Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.; Disclaimer; Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.; Biochem/physiol Actions; NFIL3 is a basic leucine zipper (bZIP) transcription factor that represses or activates transcription in non-osteoblastic cells. NFIL3 play a role in attenuation of PTH target gene transcription in osteoblasts. NFIL3 repression domain interacts specifically with the TBP binding repressor protein Dr1.Glucocorticoid-mediated upregulation of the bZIP transcriptional repressor gene, NFIL3, is dependent on [Ca2+]i levels, and correlates with Glucocorticoid-evoked apoptosis of Glucocorticoid-sensitive CEM-C7-14 cells. NFIL3 is involved in a distinct growth factor-regulated signaling pathway that is responsible for the survival of early B-cell progenitors, and whose alteration by E2A-HLF leads to childhood B lineage leukemia.; Sequence; Synthetic peptide located within the following region: GYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIHSPV