Description_x000D_ General description_x000D_ NOS3 (nitric oxide synthase 3) is located on human chromosome 7q36._x000D_ Immunogen_x000D_ Peptide sequence around aa. 1175-1179 (T-Q-S-F-S), according to the protein NOS3._x000D_ Application_x000D_ Anti-NOS3 (Ab-1177) antibody has been used in western blotting._x000D_ Target description_x000D_ Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets._x000D_ Physical form_x000D_ Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol_x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Modifications in the NOS3 (nitric oxide synthase 3) gene leads to erectile dysfunction susceptibility, age of onset and severity. In heart, NOS3 helps in NO (nitric oxide) synthesis. It also controls vascular tone and blood pressure._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.