Description_x000D_ General description_x000D_ The NOTCH2 (notch 2) gene is mapped to human chromosome 1p12. Anti-NOTCH2 (cleaved-Ala1734) antibody detects endogenous levels of fragment of activated NOTCH2 (cleaved-Ala1734) protein._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human NOTCH2._x000D_ Immunogen Range: 1715-1764_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ The NOTCH2 (notch2) gene is known to be involved in the proliferation and cell cycle progression in cancer cells. Upregulation of the gene is observed in salivary adenoid cystic carcinoma, and hepatocellular carcinoma. Deletion of NOTCH2 offers tumor cells resistance to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development. The NOTCH2 gene is associated with the development of diabetic nephropathy._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.