Description_x000D_ General description_x000D_ Anti-NOTCH4 (Cleaved-Val1432) antibody detects endogenous levels of fragment of activated NOTCH4 (Cleaved-Val1432) protein._x000D_ The NOTCH4 gene is mapped to human chromosome 6p21.32._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human NOTCH4._x000D_ Immunogen Range: 1401-1450_x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ The NOTCH4 gene is associated with the process of angiogenesis and homeostasis during developmental process. NOTCH4 plays a role in Notch signaling pathway which mediates epithelial cell and stem cell homeostasis. Notch signaling pathway is induced in a number of cancer types including colon, breast, pancreatic, cervical, head and neck, renal carcinoma, prostate cancer, Large-cell and Hodgkin lymphomas.Thus, NOTCH4 is known to participate in tumorigenesis. This gene is involved in the development of central nervous system and controls neuronal maturation. Mutations in the gene might be associated with schizophrenia._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.