Description_x000D_ General description_x000D_ Anti-p38 MAPK Antibody detects endogenous levels of total p38 MAPK protein._x000D_ p38 mitogen-activated protein kinase (MAPK), also known as, mitogen-activated protein kinase 14 (MAPK14)/ p38α, is encoded by the gene mapped on human chromosome 6p21.31. The encoded protein is a Ser/Thr kinase composed of 90 to 360 residues. p38α MAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus._x000D_ Immunogen_x000D_ The antiserum was produced against synthesized peptide derived from human p38 MAPK._x000D_ Immunogen Range: 147-196_x000D_ Application_x000D_ Anti-p38 MAPK antibody produced in rabbit has been used in western blot analysis._x000D_ Physical form_x000D_ Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ p38 mitogen-activated protein kinase (MAPK)/MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Genetic variation in p38α leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes._x000D_ Features and Benefits_x000D_ Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.