Description_x000D_ General description_x000D_ This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified. (provided by RefSeq)_x000D_ Immunogen_x000D_ PANK1 (NP_683879.1, 1 a.a. ~ 373 a.a) full-length human protein._x000D_ Sequence_x000D_ MKLINGKKQTFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDDK_x000D_ Physical form_x000D_ Solution in phosphate buffered saline, pH 7.4_x000D_ Biochem/physiol Actions_x000D_ Pantothenate kinase (PanK1) majorly participates in the maintenance of metabolic homeostasis as well as intracellular CoA concentration by stimulating the biosynthesis of coenzyme A. The centrally located catalytic core of the protein forms a homodimeric structure by coupling with acetyl-CoA. Latter, it facilitates the rate limiting phosphorylation step of vitamin B5, pantothenate. Mutation in Pank1 is associated with neurodegeneration disorder.